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KMID : 1137020170280050006
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Journal of Gynecologic Oncology
2017 Volume.28 No. 5 p.6 ~ p.6
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Role of active and passive smoking in high-risk human papillomavirus infection and cervical intraepithelial neoplasia grade 2 or worse
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Feng Rui Mei
Hu Shang Ying
Zhao Fang Hui
Zhang Rong
Zhang Xun
Wallach Asya Izraelit
Qiao You Lin
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Abstract
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Objective: We performed a pooled analysis to examine cigarette smoking and household passive smoke exposure in relation to the risk of human papillomavirus (HPV) infection and cervical intraepithelial neoplasia grade 2+ (CIN2+).
Methods: Data were pooled from 12 cross-sectional studies for cervical cancer screenings from 10 provinces of China in 1999?2007. A total of 16,422 women were analyzed, along with 2,392 high-risk-HPV (hr-HPV) positive women and 381 CIN2+ cases. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression models controlling for sexual and non-sexual confounding factors.
Results: There was an excess risk between active smoking and hr-HPV infection and CIN2+. Adjusted OR for ever smokers vs. never smokers was 1.45 (95% CI=1.10?1.91), for hr-HPV infection and 1.89 (95% CI=1.03?3.44), for CIN2+. Passive smoking had a slightly increased risk on the hr-HPV infection with adjusted OR 1.11 (1.00?1.24), but no statistical association was observed between passive smoke exposure and CIN2+. Compared with the neither active nor passive smokers, both active and passive smokers had a 1.57-fold (95% CI=1.14?2.15) increased risk of HPV infection and a 1.99-fold (95% CI=1.02?3.88) risk of CIN2+.
Conclusion: Our large multi-center cross-sectional study found active smoking could increase the risk of overall hr-HPV infection and CIN2+ adjusted by passive smoking and other factors. Passive smoking mildly increased the risk of HPV infection but not the CIN2+. An interaction existed between passive tobacco exposure and active smoking for hr-HPV infection and the CIN2+.
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KEYWORD
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Cervical Intraepithelial Neoplasia, Papillomaviridae, Infection, Smoking, Tobacco Smoke Pollution, Chinese, Women
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